Julie Bossuyt studies the molecular mechanisms that drive activation and function of the related kinases, protein kinase D and calmodulin dependent protein kinase in healthy and failing hearts. Her lab focuses on understanding the local regulatory mechanisms that control the myriad cellular outcomes for these multifunctional kinases. Tools in the lab include cutting-edge high resolution fluorescence imaging techniques (such as FRET, TIRF, FRAP and confocal) and novel biosensors to obtain unique insight into the spatiotemporal dynamics of signaling in cardiac cells.

Impaired protein degradation is associated with many cardiac and skeletal muscle diseases. Our laboratory is interested in investigating the signaling pathways involved in proteostasis (protein homeostasis) in cardiac and skeletal muscle diseases. Our laboratory is also interested in the side effects of commonly used drugs, such as ibuprofen, on the heart and other tissues.

David Furlow studes the molecular basis of hormone action, particularly during development. Analysis of gene expression programs during morphogenesis. Genome editing in model organisms, particularly applied to nuclear hormone receptor function.