Rett syndrome, a common neurodevelopmental disorder in girls, alters motor skills and cognition, with disruptions in digestion and metabolism frequently occurring in affected individuals. The Janine LaSalle lab, including Demario Chappell -- MCBGAP alumnus and current med student at Albert Einstein Medical College -- have identified new pathways of the progression of Rett Syndrome, with changes in the gut microbiome and metabolism emerging prior to the onset of neurological symptoms. Further, they observed sexual dimorphism in disease progression within mouse models.
