Sean Burgess explores the dynamic chromosome events that occur during the process of meiosis and how these processes are integrated to achieve accurate chromosome segregation. Chromosome missegregation is one of the leading causes of birth defects in humans. The Burgess lab combines the use of a wide array of tools, including genetics, molecular biology, biochemistry and live-cell imaging using budding yeast Saccharomyces cerevisiae and zebrafish Danio rerio as model systems.