Richard McKenney is interested in the fascinating world of molecular movement. His lab studies how cells internally organize using molecular motor proteins. In particular, they focus on the microtubule cytoskeleton and the motor proteins that use this filament system for transport (kinesins and dyneins). They are interested in allosteric regulation of motor protein movement, how motor activity is balanced and coordinated, and how dysfunction in motor activity leads to human diseases such as cancer and neurodegeneration. The lab combines advanced molecular biology, biochemistry and single-molecule TIRF microscopy to address these problems.